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Finding the Perfect Erection: Endless Choices
Posted by :Miriam OwensPosted date : September 3, 2019In HealthComments Off on Finding the Perfect Erection: Endless Choices
In the clinical studies performed so far, Sildenafil, Vardenafil and Tadalafil have all been shown to be effective in inducing a significant improvement in erection in about 80% of cases. A lower success rate of around 60% can be expected in a diabetic population. An important recent study also reported that Vardenafil was considered effective by 72% of interviewed diabetics. Sildenafil is marketed with dosages of 25- 50-100 mg, Vardenafil with dosages of 5-10-20 mg and, finally, Tadalafil with dosages of 10-20 mg. The trusted doctor will indicate the most appropriate drugs and dosages. With the use of bluechew erection pills you can have the best solutions now.
Are there any unwanted side effects attributable to phosphodiesterase inhibitors?
The side effects attributable to these drugs are predominantly mild-to-moderate, and dose-dependent, and only rarely have they led to treatment interruption.
A possible how much typical collateral effect concerns an anomaly of the vision, of the colors in the blue region, with defect of blue-green discrimination. This effect, which is in itself harmless, particularly seen with Sildenafil, can be attributed to the stimulation of phosphodiesterase-6 present in the cones and rods of the retina. It has not been found or is rarer with the use of Vardenafil and Tadalafil, more specific for phosphodiesterase-5 and of poor selectivity for phosphodiesterase-6.
Other side effects consisting of headache, “flushing” (redness) and rhinitis (stuffy nose) are to be attributed to the phosphodiesterase inhibition of the vascular smooth muscle, with consequent vasodilation in the various districts involved. Dyspepsia (burning, epigastric weight) is due to the involvement of the musculature of the gastro-esophageal junction. Muscle pain and back pain, observed with Tadalafil, are attributable to the inhibition of phosphodiesterase-11, present in the vessel wall of skeletal muscles.
All the side effects derive therefore from the inhibition of various phosphodiesterase isoforms present in the various organs and tissues and the effects are as minor as the exclusive specificity for phosphodiesterase-5 present in the penis is greater.
What are the contraindications to the use of these drugs?
Since all the drugs of this class act by increasing the availability of nitroxide, their use in combination with nitrates, commonly used in the treatment and prevention of angina pectoris and more generally in coronary heart disease, is prohibited. Nitrates in fact induce the generation of nitric oxide which, in synergy with a phosphodiesterase inhibitor, can determine a critical reduction in blood pressure.
There is therefore an absolute contraindication to the use of these drugs in combination, both constant and occasional, with the nitroderivatives administered orally, such as transdermally (patches). The use of phosphodiesterase inhibitors is contraindicated in subjects suffering from severe cardiopathies, even in the absence of nitrate use but, in this case, it is the sexual activity itself that is not recommended even before the use of the drug.
In conclusion, it can be considered that, apart from these limited contraindications, the use of phosphodiesterase inhibitors is, in addition to being effective in a large proportion of patients, completely safe. In any case, their prescription must remain the exclusive responsibility of the doctor who knows the mechanism of action, and is therefore able to establish the appropriateness of their use, in relation to the pathology present in the individual patients.